Three-dimensional structure of the human immunodeficiency virus-type 1 (HIV-1) nucleocapsid protein (NC) bound to the SL3 stem-loop recognition element of the genomic -RNA packaging signal. The structure was determined by heteronuclear magnetic resonance spectroscopy.

See reference: De Guzman, R.N., Rong Wu, Z., Stalling, C.C., Pappalardo, L., Borer, P.N., Summers, M.F. (1998) Structure of the HIV-1 Nucleocapsid Protein Bound to the SL3 -RNA Recognition Element. Science. 279, 384-388.

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Dr Michael Summers, investigator of Howard Hughes Medical Institute at University of Maryland, Baltimore county is primarily engaged in the research on application of nuclear magnetic resonance (NMR) to studies of the structure and function of proteins and macromolecular interactions. Nuclear magnetic resonance (NMR) and computational methods are employed in the laboratory to address protein-protein and protein-RNA interactions that occur as retroviruses assemble in infected cells. Read more...